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Victoria Nadalin1,*, Nancy Kreiger1,2, Marie-Elise Parent3, Alan Salmoni4, Andrea Sass-Kortsak5, Jack Siemiatycki6, Margaret Sloan1 and James Purdham51Research, Prevention and Cancer Control, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada M5G 2L7 2Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, Ontario, Canada M5T 3M7 3Institut Armand Frappier, Institut National de la Recherche Scientifique, Universite de Quebec, 531, boulevard des Prairies, Laval, Québec, Canada H7V 1B7 4School of Kinesiology, Faculty of Health Sciences, Western University, London, Ontario, Canada N6A 5B9 5Occupational and Environmental Health, Gage Occupational & Environmental Health Unit, 223 College St., Toronto, Ontario, Canada M5T 1R4 6Department of Social and Preventive Medicine, University of Montreal, PO Box 6128, Station Centre-ville, Montréal, Quebec, Canada H3C 3J7 ?* Author to whom correspondence should be addressed. Tel: (416)-971-9800 ext. 3251; fax: (416)-971-7554; e-mail: Victoria.nadalin{at}cancercare.on.ca Received July 6, 2011. Accepted February 3, 2012. Prostate cancer is common and its etiology largely unknown; therefore, it is important to explore all potential risk factors that are biologically plausible. Recent literature suggests a relationship between whole-body vibration (WBV) and prostate cancer risk. The aim of this study was to determine whether occupational WBV was a risk factor for prostate cancer. Existing data, collected on 447 incident cases and 532 population controls (or their proxies), in Montreal, Canada, were used to evaluate this question. Personal interviews collected detailed job descriptions for every job held, the tasks involved, and type of equipment used. For each job, experts assessed the intensity and daily duration of WBV exposure. Inter-rater agreement for WBV ratings was examined using the kappa statistic, with values that ranged from 0.83 to 0.94. Logistic regression models explored the relationship between WBV exposure and prostate cancer, using various combinations of intensity, daily duration, and years of exposure. Potential confounders were also examined. Occupations with WBV exposure demonstrated an increased statistically non-significant risk [odds ratio (OR) = 1.44, 95% confidence interval (CI): 0.99–2.09]. The risk for transport equipment operation, a job with WBV exposure, was significantly elevated (OR = 1.90, 95% CI: 1.07–3.39). These results, together with those of an earlier study, suggest that workers in heavy equipment and transport equipment operation may have increased risk of prostate cancer. Further investigation is warranted. © The Author 2012. Published by Oxford University Press on behalf of the British Occupational Hygiene Society [2012]This ArticleAnn Occup Hyg (2012) 56 (8): 968-974. doi: 10.1093/annhyg/mes010 First published online: April 26, 2012 Current Issue
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